Determining the Effectiveness of Dr. Thai's Rapid Nerve Rescue CBD Cream for Patient's Neuropathic Symptoms  

by Dr. Bao Thai, DC

 

ABSTRACT / INTRODUCTION

Neuropathy is a devastating condition that continues to affect more people around the world every year. The rise in cases is directly related to the increase in diabetes and poor lifestyle choices. Medication side effects and surgery induced neuropathy also accounts for the increase. The core cause of neuropathic symptoms is due to either axonal degeneration or myelin destruction, both of which are typically caused by neuro inflammation that occurs. My hypothesis is if you can consistently decrease the inflammation and decrease neuronal hypersensitivity at the site, that patients will experience a reduction in symptoms.

 

METHODS

The cream that was developed went through many rounds of reformulation. We decided upon 1500 mg of a high-quality CBD that was tested to have 0% THC. The dosage chosen was based on research studies. Then we combined the CBD with Agmatine Sulfate, Alpha-Ketoglutarate, and a proprietary terpene blend. The combination of the CBD, amino acids, and terpenes were determined by past studies to be a safe option for the treatment of neuropathic symptoms. Our study was comprised of 300 patient visits. These patients were all current patients receiving treatment for neuropathic symptoms. The patients were instructed to use the cream 3x a day -  One application in the morning, afternoon, and at night. This was done over a 4-week time frame. Before use, the symptoms reported by the patients ranged from pain to numbness and tingling. 

 

RESULTS:

The outcome for our study was incredibly positive. Our patients reported that they all noticed at least a 50% reduction in symptoms with the use of our cream. 85% of the patients reported that they were able to reduce their use of pain meds completely or by half. 70% of the patients noticed an immediate change. 60% reported it took only 3 days of use to notice a significant change. 20% said it took 2 weeks of use to notice a significant change. It is worth to note that the patients that took 2 weeks for change all were very severe cases of neuropathy. 100% of patients reported that they would rather use the cream VS their prescription meds due to the side effects and lack of effectiveness. These initial findings are incredibly important as they provide evidence for the use in treating neuropathic symptoms without having negative side effects for patients. 

Rapid Nerve Rescue Reference /

 

 

Citation

Xu DH, Cullen BD, Tang M, Fang Y. The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities. Curr Pharm Biotechnol. 2020;21(5):390-402. doi: 10.2174/1389201020666191202111534. PMID: 31793418.

 

de Almeida DL, Devi LA. Diversity of molecular targets and signaling pathways for CBD. Pharmacol Res Perspect. 2020 Dec;8(6):e00682. doi: 10.1002/prp2.682. PMID: 33169541; PMCID: PMC7652785.

 

Philpott HT, O'Brien M, McDougall JJ. Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. Pain. 2017 Dec;158(12):2442-2451. doi: 10.1097/j.pain.0000000000001052. PMID: 28885454; PMCID: PMC5690292.

 

Anand U, Jones B, Korchev Y, Bloom SR, Pacchetti B, Anand P, Sodergren MH. CBD Effects on TRPV1 Signaling Pathways in Cultured DRG Neurons. J Pain Res. 2020 Sep 11;13:2269-2278. doi: 10.2147/JPR.S258433. PMID: 32982390; PMCID: PMC7494392.

 

Gilad GM, Gilad VH. Long-term (5 years), high daily dosage of dietary agmatine--evidence of safety: a case report. J Med Food. 2014 Nov;17(11):1256-9. doi: 10.1089/jmf.2014.0026. Epub 2014 Sep 23. PMID: 25247837.

 

Rosenberg ML, Tohidi V, Sherwood K, Gayen S, Medel R, Gilad GM. Evidence for Dietary Agmatine Sulfate Effectiveness in Neuropathies Associated with Painful Small Fiber Neuropathy. A Pilot Open-Label Consecutive Case Series Study. Nutrients. 2020 Feb 23;12(2):576. doi: 10.3390/nu12020576. PMID: 32102167; PMCID: PMC7071502.

 

Wax B, Kavazis AN, Webb HE, Brown SP. Acute L-arginine alpha ketoglutarate supplementation fails to improve muscular performance in resistance trained and untrained men. J Int Soc Sports Nutr. 2012 Apr 17;9(1):17. doi: 10.1186/1550-2783-9-17. PMID: 22510253; PMCID: PMC3428651. 

 

Willoughby DS, Boucher T, Reid J, Skelton G, Clark M. Effects of 7 days of arginine-alpha-ketoglutarate supplementation on blood flow, plasma L-arginine, nitric oxide metabolites, and asymmetric dimethyl arginine after resistance exercise. Int J Sport Nutr Exerc Metab. 2011 Aug;21(4):291-9. doi: 10.1123/ijsnem.21.4.291. PMID: 21813912.

 

Continued Reference / Citation

Mecha M, Feliú A, Iñigo PM, Mestre L, Carrillo-Salinas FJ, Guaza C. Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: a role for A2A receptors. Neurobiol Dis. 2013 Nov;59:141-50. doi: 10.1016/j.nbd.2013.06.016. Epub 2013 Jul 11. PMID: 23851307.

 

Esraa Aly, Willias Masocha, Targeting the endocannabinoid system for management of HIV-associated neuropathic pain: A systematic review, IBRO Neuroscience Reports, 10.1016/j.ibneur.2021.01.004, 10, (109-118), (2021).

 

Igor Dykukha, Rolf Malessa, Ute Essner, Michael A Überall, Nabiximols in Chronic Neuropathic Pain: A Meta-Analysis of Randomized Placebo-Controlled Trials, Pain Medicine, 10.1093/pm/pnab050, 22, 4, (861-874), (2021).

 

Taurean Brown, DeLawrence Sykes, Antiño R. Allen, Implications of Breast Cancer Chemotherapy-Induced Inflammation on the Gut, Liver, and Central Nervous System, Biomedicines, 10.3390/biomedicines9020189, 9, 2, (189), (2021).

 

Dixon H. Xu, Benjamin D. Cullen, Meng Tang, Yujiang Fang, The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities, Current Pharmaceutical Biotechnology, 10.2174/1389201020666191202111534, 21, 5, (390-402), (2020).

 

VanDolah HJ, Bauer BA, Mauck KF. Clinicians' Guide to Cannabidiol and Hemp Oils. Mayo Clin Proc. 2019 Sep;94(9):1840-1851. doi: 10.1016/j.mayocp.2019.01.003. Epub 2019 Aug 22. PMID: 31447137.

 

Baron EP. Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science. Headache. 2018 Jul;58(7):1139-1186. doi: 10.1111/head.13345. PMID: 30152161.

 

Eskander JP, Spall J, Spall A, Shah RV, Kaye AD. Cannabidiol (CBD) as a treatment of acute and chronic back pain: A case series and literature review. J Opioid Manag. 2020 May/Jun;16(3):215-218. doi: 10.5055/jom.2020.0570. PMID: 32421842.